The recognition of a viral antigenic moiety by class I MHC-restricted cytolytic T lymphocytes is limited by the availability of the endogenously processed antigen
Identifieur interne : 002129 ( Main/Exploration ); précédent : 002128; suivant : 002130The recognition of a viral antigenic moiety by class I MHC-restricted cytolytic T lymphocytes is limited by the availability of the endogenously processed antigen
Auteurs : G. N. Milligan [États-Unis] ; L. A. Morrison [États-Unis] ; J. Gorka ; V. L. Braciale [États-Unis] ; T. J. Braciale [États-Unis]Source :
- (The) Journal of immunology : (Baltimore, MD. 1950) [ 0022-1767 ] ; 1990.
Descripteurs français
- KwdFr :
- Animaux, Antigènes d'histocompatibilité de classe I (immunologie), Antigènes viraux (immunologie), Données de séquences moléculaires, Femelle, Glycoprotéine hémagglutinine du virus influenza, Hémagglutinines virales (génétique), Hémagglutinines virales (immunologie), Hémagglutinines virales (physiologie), Lymphocytes T cytotoxiques (immunologie), Peptides (immunologie), Souris, Souris de lignée BALB C, Séquence d'acides aminés, Virus de la grippe A (immunologie), Épitopes.
- MESH :
- génétique : Hémagglutinines virales.
- immunologie : Antigènes d'histocompatibilité de classe I, Antigènes viraux, Hémagglutinines virales, Lymphocytes T cytotoxiques, Peptides, Virus de la grippe A.
- physiologie : Hémagglutinines virales.
- Pascal (Inist)
- Animaux, Données de séquences moléculaires, Femelle, Glycoprotéine hémagglutinine du virus influenza, Souris, Influenzavirus, Reconnaissance, Souris de lignée BALB C, Système H-2, Système histocompatibilité majeur, Lymphocyte T, Antigène histocompatibilité classe I, Cytotoxicité, Maturation moléculaire, Présentation antigène, Peptide, Produit synthétique, Séquence d'acides aminés, Épitopes.
English descriptors
- KwdEn :
- Amino Acid Sequence, Animals, Antigen presentation, Antigens, Viral (immunology), Class I histocompatibility antigen, Cytotoxicity, Epitopes, Female, H-2-System, Hemagglutinin Glycoproteins, Influenza Virus, Hemagglutinins, Viral (genetics), Hemagglutinins, Viral (immunology), Hemagglutinins, Viral (physiology), Histocompatibility Antigens Class I (immunology), Influenza A virus (immunology), Influenzavirus, Major histocompatibility system, Mice, Mice, Inbred BALB C, Molecular Sequence Data, Molecular processing, Mouse, Peptides, Peptides (immunology), Recognition, Synthetic product, T-Lymphocyte, T-Lymphocytes, Cytotoxic (immunology).
- MESH :
- chemical , genetics : Hemagglutinins, Viral.
- chemical , immunology : Antigens, Viral, Hemagglutinins, Viral, Histocompatibility Antigens Class I, Peptides.
- chemical , physiology : Hemagglutinins, Viral.
- immunology : Influenza A virus, T-Lymphocytes, Cytotoxic.
- Amino Acid Sequence, Animals, Epitopes, Female, Hemagglutinin Glycoproteins, Influenza Virus, Mice, Mice, Inbred BALB C, Molecular Sequence Data.
Abstract
The transmembrane hydrophobic domain of the type A influenza A/JAPAN/305/57 (H2N2) hemagglutinin (HA) contains an immunodominant site encompassing amino acids 523-545 (J523-545) recognized by class I MHC-restricted cytolytic T lymphocytes (CTL). Class I CTL of two fine specificity subsets map to this transmembrane (TM) site. One of these CTL subpopulations is subtype specific
Affiliations:
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N." last="Milligan">G. N. Milligan</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Washington univ. school medicine, Howard-Hughes medical inst., dep. pathology</s1><s2>Saint Louis MO 63110</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Saint Louis MO 63110</wicri:noRegion></affiliation></author><author><name sortKey="Morrison, L A" sort="Morrison, L A" uniqKey="Morrison L" first="L. A." last="Morrison">L. A. Morrison</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Washington univ. school medicine, Howard-Hughes medical inst., dep. pathology</s1><s2>Saint Louis MO 63110</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Saint Louis MO 63110</wicri:noRegion></affiliation></author><author><name sortKey="Gorka, J" sort="Gorka, J" uniqKey="Gorka J" first="J." last="Gorka">J. Gorka</name></author><author><name sortKey="Braciale, V L" sort="Braciale, V L" uniqKey="Braciale V" first="V. L." last="Braciale">V. L. Braciale</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Washington univ. school medicine, Howard-Hughes medical inst., dep. pathology</s1><s2>Saint Louis MO 63110</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Saint Louis MO 63110</wicri:noRegion></affiliation></author><author><name sortKey="Braciale, T J" sort="Braciale, T J" uniqKey="Braciale T" first="T. J." last="Braciale">T. J. Braciale</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Washington univ. school medicine, Howard-Hughes medical inst., dep. pathology</s1><s2>Saint Louis MO 63110</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Saint Louis MO 63110</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">(The) Journal of immunology : (Baltimore, MD. 1950)</title><title level="j" type="abbreviated">J. immunol. : (Baltim. MD, 1950)</title><idno type="ISSN">0022-1767</idno><imprint><date when="1990">1990</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">(The) Journal of immunology : (Baltimore, MD. 1950)</title><title level="j" type="abbreviated">J. immunol. : (Baltim. MD, 1950)</title><idno type="ISSN">0022-1767</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Antigen presentation</term><term>Antigens, Viral (immunology)</term><term>Class I histocompatibility antigen</term><term>Cytotoxicity</term><term>Epitopes</term><term>Female</term><term>H-2-System</term><term>Hemagglutinin Glycoproteins, Influenza Virus</term><term>Hemagglutinins, Viral (genetics)</term><term>Hemagglutinins, Viral (immunology)</term><term>Hemagglutinins, Viral (physiology)</term><term>Histocompatibility Antigens Class I (immunology)</term><term>Influenza A virus (immunology)</term><term>Influenzavirus</term><term>Major histocompatibility system</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Molecular Sequence Data</term><term>Molecular processing</term><term>Mouse</term><term>Peptides</term><term>Peptides (immunology)</term><term>Recognition</term><term>Synthetic product</term><term>T-Lymphocyte</term><term>T-Lymphocytes, Cytotoxic (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antigènes d'histocompatibilité de classe I (immunologie)</term><term>Antigènes viraux (immunologie)</term><term>Données de séquences moléculaires</term><term>Femelle</term><term>Glycoprotéine hémagglutinine du virus influenza</term><term>Hémagglutinines virales (génétique)</term><term>Hémagglutinines virales (immunologie)</term><term>Hémagglutinines virales (physiologie)</term><term>Lymphocytes T cytotoxiques (immunologie)</term><term>Peptides (immunologie)</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Séquence d'acides aminés</term><term>Virus de la grippe A (immunologie)</term><term>Épitopes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Hemagglutinins, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Viral</term><term>Hemagglutinins, Viral</term><term>Histocompatibility Antigens Class I</term><term>Peptides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Hemagglutinins, Viral</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Hémagglutinines virales</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes d'histocompatibilité de classe I</term><term>Antigènes viraux</term><term>Hémagglutinines virales</term><term>Lymphocytes T cytotoxiques</term><term>Peptides</term><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A virus</term><term>T-Lymphocytes, Cytotoxic</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Hémagglutinines virales</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Epitopes</term><term>Female</term><term>Hemagglutinin Glycoproteins, Influenza Virus</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Molecular Sequence Data</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Animaux</term><term>Données de séquences moléculaires</term><term>Femelle</term><term>Glycoprotéine hémagglutinine du virus influenza</term><term>Souris</term><term>Influenzavirus</term><term>Reconnaissance</term><term>Souris de lignée BALB C</term><term>Système H-2</term><term>Système histocompatibilité majeur</term><term>Lymphocyte T</term><term>Antigène histocompatibilité classe I</term><term>Cytotoxicité</term><term>Maturation moléculaire</term><term>Présentation antigène</term><term>Peptide</term><term>Produit synthétique</term><term>Séquence d'acides aminés</term><term>Épitopes</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The transmembrane hydrophobic domain of the type A influenza A/JAPAN/305/57 (H2N2) hemagglutinin (HA) contains an immunodominant site encompassing amino acids 523-545 (J523-545) recognized by class I MHC-restricted cytolytic T lymphocytes (CTL). Class I CTL of two fine specificity subsets map to this transmembrane (TM) site. One of these CTL subpopulations is subtype specific</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Gorka, J" sort="Gorka, J" uniqKey="Gorka J" first="J." last="Gorka">J. Gorka</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Milligan, G N" sort="Milligan, G N" uniqKey="Milligan G" first="G. N." last="Milligan">G. N. Milligan</name></noRegion><name sortKey="Braciale, T J" sort="Braciale, T J" uniqKey="Braciale T" first="T. J." last="Braciale">T. J. Braciale</name><name sortKey="Braciale, V L" sort="Braciale, V L" uniqKey="Braciale V" first="V. L." last="Braciale">V. L. Braciale</name><name sortKey="Morrison, L A" sort="Morrison, L A" uniqKey="Morrison L" first="L. A." last="Morrison">L. A. Morrison</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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